Discovery of Novel Compounds for Combating Rising Severity of Plant Diseases Caused by Fungi and Viruses.

ABSTRACT: In recent years, the severity of plant diseases caused by plant pathogenic fungi and viruses has been on the rise. However, there is a limited availability of pesticide chemicals in the market for effectively controlling both fungal and viral infections. To solve this problem, a series of novel pyrimidine derivatives containing a 1,3,4-oxadiazole thioether fragment were synthesized. Among them, compound 6s exhibited remarkable in vivo protection activity against tobacco mosaic virus, demonstrating the superior 50% effective concentration (EC₅₀) value of 0.42 μM, outperforming ningnanmycin (0.60 μM). Meanwhile, compound 6s exhibited remarkable antifungal activity against Botrytis cinerea Pers. in postharvest blueberry in vitro, with an EC₅₀ value o

SUBMITTER: Pan N 

PROVIDER: S-EPMC10785787 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature