Seeking for Innovation with Magnetic Resonance Imaging Paramagnetic Contrast Agents: Relaxation Enhancement via Weak and Dynamic Electrostatic Interactions with Positively Charged Groups on Endogenous Macromolecules.

ABSTRACT: Gd-L1 is a macrocyclic Gd-HPDO3A derivative functionalized with a short spacer to a trisulfonated pyrene. When compared to Gd-HPDO3A, the increased relaxivity appears to be determined by both the higher molecular weight and the occurrence of an intramolecularly catalyzed prototropic exchange of the coordinated OH moiety. In water, Gd-L1 displayed a relaxivity of 7.1 mM^-1 s^-1 (at 298 K and 0.5 T), slightly increasing with the concentration likely due to the onset of intermolecular aggregation. A remarkably high and concentration-dependent relaxivity was measured in human serum (up to 26.5 mM^-1 s^-1 at the lowest tested concentration of 0.005 mM). The acquisition of ¹H-nuclear magnetic relaxation dispersion (NMRD) and ¹⁷O-R<

SUBMITTER: Stefania R 

PROVIDER: S-EPMC10785807 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature