Latency for All: Enabling Latency of Hoveyda-Grubbs Second-Generation Catalysts by Adding Phosphite Ligands.

ABSTRACT: The Hoveyda-Grubbs catalyst (HG2, M720 Umicore) is among the most widely used catalysts in olefin metathesis reactions. Given the usefulness of HG2 and the great interest in developing latent olefin metathesis catalysts for numerous applications, we developed a method to introduce phosphite molecules as ancillary ligands into the precatalyst framework. This modification alters the geometry of the complex from an active trans-dichloro form to a latent cis-dichloro species. Most unusually, the ligands coordinate to HG2 only in solidified solutions (most likely due to entropic factors), providing latent catalysts that can be activated on demand by heat or light by regenerating the original HG2 catalyst. Of particular interest is the use of these laten

SUBMITTER: Vaisman A 

PROVIDER: S-EPMC10785811 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature