Force-Regulated Spontaneous Conformational Changes of Integrins α₅β₁ and α_Vβ₃.

ABSTRACT: Integrins are cell surface nanosized receptors crucial for cell motility and mechanosensing of the extracellular environment, which are often targeted for the development of biomaterials and nanomedicines. As a key feature of integrins, their activity, structure and behavior are highly mechanosensitive, which are regulated by mechanical forces down to pico-Newton scale. Using single-molecule biomechanical approaches, we compared the force-modulated ectodomain bending/unbending conformational changes of two integrin species, α₅β₁ and α_Vβ₃. It was found that the conformation of integrin α₅β₁ is determined by a threshold head-to-tail tension. By comparison, integrin α_Vβ₃ exhibits bistability even without f

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10786158 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature