Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies.

ABSTRACT: Bacterial cells require DNA segregation machinery to properly distribute a genome to both daughter cells upon division. The most common system involved in chromosome and plasmid segregation in bacteria is the ParABS system. A core protein of this system - partition protein B (ParB) - regulates chromosome organization and chromosome segregation during the bacterial cell cycle. Over the past decades, research has greatly advanced our knowledge of the ParABS system. However, many intricate details of the mechanism of ParB proteins were only recently uncovered using in vitro single-molecule techniques. These approaches allowed the exploration of ParB proteins in precisely controlled environments, free from the complexities of the cellular milieu. This review covers the early developments of th

SUBMITTER: Tisma M 

PROVIDER: S-EPMC10786196 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature