Effect of Malaria Infection on Epstein-Barr Virus Persistence in Kenyan Children.

ABSTRACT:

Background

The 2 cofactors in the etiology of Burkitt lymphoma (BL) are Epstein-Barr virus (EBV) and repeated Plasmodium falciparum malaria infections. This study evaluated EBV loads in mucosal and systemic compartments of children with malaria and controls. Age was analyzed as a covariate because immunity to malaria in endemic regions is age dependent.

Methods

Children (2-10 years) with clinical malaria from Western Kenya and community controls without malaria were enrolled. Saliva and blood samples were collected, EBV viral load was assessed by quantitative polymerase chain reaction, and EpiTYPER MassARRAY was used to assess methylation of 3 different EBV genes.

Results

Regardless of the compartment, we detected EBV more frequently in malaria cases compared to contr

SUBMITTER: Samayoa-Reyes G 

PROVIDER: S-EPMC10786253 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature