Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals.

ABSTRACT: Repeating patterns of synovial joints are a highly conserved feature of articulated digits, with variations in joint number and location resulting in diverse digit morphologies and limb functions across the tetrapod clade. During the development of the amniote limb, joints form iteratively within the growing digit ray, as a population of distal progenitors alternately specifies joint and phalanx cell fates to segment the digit into distinct elements. While numerous molecular pathways have been implicated in this fate choice, it remains unclear how they give rise to a repeating pattern. Here, using single-cell RNA sequencing and spatial gene expression profiling, we investigate the transcriptional dynamics of interphalangeal joint specification in vivo. Combined with mathematical modeling,

SUBMITTER: Grall E 

PROVIDER: S-EPMC10786279 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature