A general approach for inferring the ancestry of recent ancestors of an admixed individual.

ABSTRACT: The genome of an individual from an admixed population consists of segments originated from different ancestral populations. Most existing ancestry inference approaches focus on calling these segments for the extant individual. In this paper, we present a general ancestry inference approach for inferring recent ancestors from an extant genome. Given the genome of an individual from a recently admixed population, our method can estimate the proportions of the genomes of the recent ancestors of this individual that originated from some ancestral populations. The key step of our method is the inference of ancestors (called founders) right after the formation of an admixed population. The inferred founders can then be used to infer the ancestry of recent ancestors of an extant individual. Our

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10786287 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature