Longevity, demographic characteristics, and socio-economic status are linked to triiodothyronine levels in the general population.

ABSTRACT: The hypothalamic-pituitary-thyroid (HPT) axis is fundamental to human biology, exerting central control over energy expenditure and body temperature. However, the consequences of normal physiologic HPT-axis variation in populations without diagnosed thyroid disease are poorly understood. Using nationally representative data from the 2007 to 2012 National Health and Nutrition Examination Survey, we explore relationships with demographic characteristics, longevity, and socio-economic factors. We find much larger variation across age in free T3 than other HPT-axis hormones. T3 and T4 have opposite relationships to mortality: free T3 is inversely related and free T4 is positively related to the likelihood of death. Free T3 and household income are negatively related, particularly at lower inco

SUBMITTER: Lawton RI 

PROVIDER: S-EPMC10786306 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature