Gut metabolite L-lactate supports Campylobacter jejuni population expansion during acute infection.

ABSTRACT: How the microaerobic pathogen Campylobacter jejuni establishes its niche and expands in the gut lumen during infection is poorly understood. Using 6-wk-old ferrets as a natural disease model, we examined this aspect of C. jejuni pathogenicity. Unlike mice, which require significant genetic or physiological manipulation to become colonized with C. jejuni, ferrets are readily infected without the need to disarm the immune system or alter the gut microbiota. Disease after C. jejuni infection in ferrets reflects closely how human C. jejuni infection proceeds. Rapid growth of C. jejuni and associated intestinal inflammation was observed within 2 to 3 d of infection. We observed pathophysiological changes that were noted by cryptic hyperplasia through th

SUBMITTER: Sinha R 

PROVIDER: S-EPMC10786315 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature