TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.

ABSTRACT: Fungal infections have emerged as a major concern among immunocompromised patients, causing approximately 2 million deaths each year worldwide. However, the regulatory mechanisms underlying antifungal immunity remain elusive and require further investigation. The E3 ligase Trim26 belongs to the tripartite motif (Trim) protein family, which is involved in various biological processes, including cell proliferation, antiviral innate immunity, and inflammatory responses. Herein, we report that Trim26 exerts protective antifungal immune functions after fungal infection. Trim26-deficient mice are more susceptible to fungemia than their wild-type counterparts. Mechanistically, Trim26 restricts inflammatory neutrophils infiltration and limits proinflammatory cytokine production, which can attenuat

SUBMITTER: Zhao G 

PROVIDER: S-EPMC10786383 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature