Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice.

ABSTRACT: The hygiene hypothesis proposes that decreased exposure to infectious agents in developed countries may contribute to the development of allergic and autoimmune diseases. Trichinella spiralis, a parasitic roundworm, causes trichinellosis, also known as trichinosis, in humans. T. spiralis had many hosts, and almost any mammal could become infected. Adult worms lived in the small intestine, while the larvae lived in muscle cells of the same mammal. T. spiralis was a significant public health threat because it could cause severe illness and even death in humans who eat undercooked or raw meat containing the parasite. The complex interactions between gastrointestinal helminths, gut microbiota, and the host immune system present a challenge for researchers. Two groups of mice were infected with

SUBMITTER: Sun XM 

PROVIDER: S-EPMC10786400 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature