A SIMPLE, CONSISTENT ESTIMATOR OF SNP HERITABILITY FROM GENOME-WIDE ASSOCIATION STUDIES.

ABSTRACT: Analysis of genome-wide association studies (GWAS) is characterized by a large number of univariate regressions where a quantitative trait is regressed on hundreds of thousands to millions of single-nucleotide polymorphism (SNP) allele counts, one at a time. This article proposes an estimator of the SNP heritability of the trait, defined here as the fraction of the variance of the trait explained by the SNPs in the study. The proposed GWAS heritability (GWASH) estimator is easy to compute, highly interpretable, and is consistent as the number of SNPs and the sample size increase. More importantly, it can be computed from summary statistics typically reported in GWAS, not requiring access to the original data. The estimator takes full account of the linkage disequilibrium (LD) or correlatio

SUBMITTER: Schwartzman A 

PROVIDER: S-EPMC10786410 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature