HBV infection effects prognosis and activates the immune response in intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

The impact of HBV infection on the prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains uncertain, and the underlying mechanism has not been elucidated. This study aims to explore the potential mechanism via clinical perspectives and immune features.

Methods

We retrospectively reviewed 1308 patients with ICC treated surgically from January 2007 to January 2015. Then, we compared immune-related markers using immunohistochemistry staining to obtain the gene expression profile GSE107943 and related literature for preliminary bioinformatics analysis. Subsequently, we conducted a drug sensitivity assay to validate the role of TNFSF9 in the ICC organoid-autologous immune cell coculture system and in the patient-derived organoids-based xenograft platf

SUBMITTER: Li Z 

PROVIDER: S-EPMC10786594 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature