Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.

ABSTRACT:

Background and objectives

Stiff-person syndrome (SPS) and progressive encephalomyelitis with rigidity and myoclonus (PERM) are rare neurologic disorders of the CNS. Until now, exclusive GlyRα subunit-binding autoantibodies with subsequent changes in function and surface numbers were reported. GlyR autoantibodies have also been described in patients with focal epilepsy. Autoimmune reactivity against the GlyRβ subunits has not yet been shown. Autoantibodies against GlyRα1 target the large extracellular N-terminal domain. This domain shares a high degree of sequence homology with GlyRβ making it not unlikely that GlyRβ-specific autoantibody (aAb) exist and contribute to the disease pathology.

Methods

In this study, we investigated serum samples from 58 patients for aAb specific

SUBMITTER: Wiessler AL 

PROVIDER: S-EPMC10786602 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature