Longitudinal Analysis of Retinal Microvascular and Choroidal Imaging Parameters in Parkinson's Disease Compared with Controls.

ABSTRACT:

Purpose

To quantify rate of change of retinal microvascular and choroidal structural parameters in subjects with Parkinson's disease (PD) compared with controls using OCT and OCT angiography (OCTA).

Design

Prospective longitudinal study.

Participants

Seventy-four eyes of 40 participants with PD and 149 eyes of 78 control individuals from the Eye Multimodal Imaging in Neurodegenerative Disease database.

Methods

Subjects underwent OCT and OCTA imaging at 2 time points approximately 12 months apart.

Main outcome measures

Imaging parameters included central subfield thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, peripapillary retinal nerve fiber layer thickness, choroidal vascularity index, superficial capillary plexus perfusion density (

SUBMITTER: Kundu A 

PROVIDER: S-EPMC10786668 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature