Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring.

ABSTRACT: Gestational diabetes is a common medical complication of pregnancy that is associated with adverse perinatal outcomes and an increased risk of metabolic diseases and atherosclerosis in adult offspring. The mechanisms responsible for this delayed pathological transmission remain unknown. In mouse models, we found that the development of atherosclerosis in adult offspring born to diabetic pregnancy can be in part linked to hematopoietic alterations. Although they do not show any gross metabolic disruptions, the adult offspring maintain hematopoietic features associated with diabetes, indicating the acquisition of a lasting diabetic hematopoietic memory. We show that the induction of this hematopoietic memory during gestation relies on the activity of the advanced glycation end product recept

SUBMITTER: Govindarajah V 

PROVIDER: S-EPMC10786695 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature