Lithiated porous silicon nanowires stimulate periodontal regeneration.

ABSTRACT: Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy develo

SUBMITTER: Kaasalainen M 

PROVIDER: S-EPMC10786831 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature