Identification of important genes related to HVSMC proliferation and migration in graft restenosis based on WGCNA.

ABSTRACT: The great saphenous vein is the most commonly used vessel for coronary artery bypass grafting (CABG), but its use has been associated with a high restenosis rate at 10-year follow-up. This study sought to determine the key genes associated with vein graft restenosis that could serve as novel therapeutic targets. A total of 3075 upregulated and 1404 downregulated genes were identified after transcriptome sequencing of three pairs of restenosed vein grafts and intraoperative spare great saphenous veins. Weighted gene co-expression network analysis showed that the floralwhite module had the highest correlation with vein graft restenosis. The intersection of the floralwhite module gene set and the upregulated gene set contained 615 upregulated genes strongly correlated with vein graft restenos

SUBMITTER: Liu X 

PROVIDER: S-EPMC10786872 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature