Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment.

ABSTRACT:

Background and objective

Ceftaroline fosamil is a β-lactam antibiotic approved as a 600 mg twice daily dose (≤1 h infusion, 'standard dosing') or a 600 mg thrice daily dose (2 h infusion) to treat complicated skin and soft tissue infections caused by Staphylococcus aureus (minimum inhibitory concentration [MIC] 2-4 mg/L). We sought to systematically evaluate the relative impact of the three key components of the intensified dosing regimen (i.e. shortened dosing interval, prolonged infusion duration and increased total daily dose [TDD]) on the pharmacokinetic/pharmacodynamic (PK/PD) target attainment given different grades of bacterial susceptibility.

Methods

A population PK model was developed using data from 12 healthy volunteers (EudraCT-2012-005134-11) receiving standard

SUBMITTER: Minichmayr IK 

PROVIDER: S-EPMC10786958 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature