Stress and reward in the maternal brain of mothers with borderline personality disorder: a script-based fMRI study.

ABSTRACT: Borderline personality disorder (BPD) is associated with altered neural activity in regions of salience and emotion regulation. An exaggerated sensitization to emotionally salient situations, increased experience of emotions, and dysfunctional regulative abilities could be reasons for increased distress also during parenting. Mothers with BPD tend to have less reciprocal mother-child interactions (MCI) and reveal altered cortisol and oxytocin reactivity in the interaction with their child, which could indicate altered processing of stress and reward. Here, we studied underlying neural mechanisms of disrupted MCI in BPD. Twenty-five mothers with BPD and 28 healthy mothers participated in a script-driven imagery functional magnetic resonance imaging (fMRI)-paradigm. Scripts described stressf

SUBMITTER: Schneider I 

PROVIDER: S-EPMC10786970 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature