Complement and MHC patterns can provide the diagnostic framework for inflammatory neuromuscular diseases.

ABSTRACT: Histopathological analysis stands as the gold standard for the identification and differentiation of inflammatory neuromuscular diseases. These disorders continue to constitute a diagnostic challenge due to their clinical heterogeneity, rarity and overlapping features. To establish standardized protocols for the diagnosis of inflammatory neuromuscular diseases, the development of cost-effective and widely applicable tools is crucial, especially in settings constrained by limited resources. The focus of this review is to emphasize the diagnostic value of major histocompatibility complex (MHC) and complement patterns in the immunohistochemical analysis of these diseases. We explore the immunological background of MHC and complement signatures that characterize inflammatory features, with a s

SUBMITTER: Nelke C 

PROVIDER: S-EPMC10786976 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature