Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis.

ABSTRACT: Debilitating abdominal pain is a common symptom affecting most patients with chronic pancreatitis (CP). There are multiple underlying mechanisms that contribute to CP-related pain, which makes successful treatment difficult. The identification of biomarkers for subtypes of pain could provide viable targets for nonopioid interventions and the development of mechanistic approaches to pain management in CP. Nineteen inflammation- and nociception-associated proteins were measured in serum collected from 358 subjects with definite CP enrolled in PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies, a prospective observational study of pancreatitis in US adult subjects. First, serum levels of putative biomarkers were compared between CP subjects with and wit

SUBMITTER: Saloman JL 

PROVIDER: S-EPMC10787046 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature