YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles.

ABSTRACT: Interactions between living cells and nanoparticles are extensively studied to enhance the delivery of therapeutics. Nanoparticles size, shape, stiffness, and surface charge are regarded as the main features able to control the fate of cell-nanoparticle interactions. However, the clinical translation of nanotherapies has so far been limited, and there is a need to better understand the biology of cell-nanoparticle interactions. This study investigates the role of cellular mechanosensitive components in cell-nanoparticle interactions. It is demonstrated that the genetic and pharmacologic inhibition of yes-associated protein (YAP), a key component of cancer cell mechanosensing apparatus and Hippo pathway effector, improves nanoparticle internalization in triple-negative breast cancer cells r

SUBMITTER: Cassani M 

PROVIDER: S-EPMC10787066 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature