Newfound Coding Potential of Transcripts Unveils Missing Members of Human Protein Communities.

ABSTRACT: Recent proteogenomic approaches have led to the discovery that regions of the transcriptome previously annotated as non-coding regions [i.e., untranslated regions (UTRs), open reading frames overlapping annotated coding sequences in a different reading frame, and non-coding RNAs] frequently encode proteins, termed alternative proteins (altProts). This suggests that previously identified protein-protein interaction (PPI) networks are partially incomplete because altProts are not present in conventional protein databases. Here, we used the proteogenomic resource OpenProt and a combined spectrum- and peptide-centric analysis for the re-analysis of a high-throughput human network proteomics dataset, thereby revealing the presence of 261 altProts in the network. We found 19 genes encoding both

SUBMITTER: Leblanc S 

PROVIDER: S-EPMC10787177 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature