Mechanistic description of spontaneous loss of memory persistent activity based on neuronal synaptic strength.

ABSTRACT: Persistent neural activity associated with working memory (WM) lasts for a limited time duration. Current theories suggest that its termination is actively obtained via inhibitory currents, and there is currently no theory regarding the possibility of a passive memory-loss mechanism that terminates memory persistent activity. Here, we develop an analytical-framework, based on synaptic strength, and show via simulations and fitting to wet-lab experiments, that passive memory-loss might be a result of an ionic-current long-term plateau, i.e., very slow reduction of memory followed by abrupt loss. We describe analytically the plateau, when the memory state is just below criticality. These results, including the plateau, are supported by experiments performed on rats. Moreover, w

SUBMITTER: Sanhedrai H 

PROVIDER: S-EPMC10787259 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature