Oxidative stress promotes cytotoxicity in human cancer cell lines exposed to Escallonia spp. extracts.

ABSTRACT:

Background

Standard cancer treatments show a lack of selectivity that has led to the search for new strategies against cancer. The selective elimination of cancer cells modulating the redox environment, known as "selective oxycution", has emerged as a viable alternative. This research focuses on characterizing the unexplored Escallonia genus plant extracts and evaluating their potential effects on cancer's redox balance, cytotoxicity, and activation of death pathways.

Methods

36 plant extracts were obtained from 4 different species of the Escallonia genus (E. illinita C. Presl, E. rubra (Ruiz & Pav.) Pers., E. revoluta (Ruiz & Pav.) Pers., and E. pulverulenta (Ruiz & Pav.) Pers.), which were posteriorly analyzed by their phytoconstituents, antioxidant capacity, and GC-MS. Fu

SUBMITTER: Jara-Gutierrez C 

PROVIDER: S-EPMC10787448 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature