Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity.

ABSTRACT:

Background

The visual organ plays a crucial role in sensing environmental information. However, its mucosal surfaces are constantly exposed to selective pressures from aquatic or airborne pathogens and microbial communities. Although few studies have characterized the conjunctival-associated lymphoid tissue (CALT) in the ocular mucosa (OM) of birds and mammals, little is known regarding the evolutionary origins and functions of immune defense and microbiota homeostasis of the OM in the early vertebrates.

Results

Our study characterized the structure of the OM microbial ecosystem in rainbow trout (Oncorhynchus mykiss) and confirmed for the first time the presence of a diffuse mucosal-associated lymphoid tissue (MALT) in fish OM. Moreover, the microbial communities residing on

SUBMITTER: Kong W 

PROVIDER: S-EPMC10787490 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature