Genome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer.

ABSTRACT:

Background

The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular polysaccharide (CPS) gene clusters, has been widely used for serotyping in many gram-negative bacteria. RA has been classified into at least 21 serovars based on slide agglutination, but the molecular basis of serotyping is unknown. In this study, we performed a pan-genome-wide association study (Pan-GWAS) to identify the genetic loci associated with RA serovars.

Results

The results revealed a significant association between the putative CPS synthesis gene locus and the serological phenotype. Further characterization of the CPS gene clusters in 11 represe

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10787497 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature