Improved cognition after rifaximin treatment is associated with changes in intra- and inter-brain network functional connectivity.

ABSTRACT:

Background

Rifaximin is a non-reabsorbable antibiotic which acts at gut level, and improves cognition and inflammatory parameters in minimal hepatic encephalopathy (MHE) patients, but not all patients show the same level of response. This study aims to assess brain activity, both within and between brain networks, following rifaximin treatment, considering the differences between response groups as well.

Methods

Twenty-two healthy controls and 53 patients with cirrhosis (22 without and 31 with MHE, diagnosed by Psychometric Hepatic Encephalopathy Score, PHES) performed psychometric, attention and coordination tests, and blood inflammatory parameters were measured. Resting-state functional magnetic resonance imaging (fMRI) acquisitions were performed on controls and MHE patie

SUBMITTER: Casanova-Ferrer F 

PROVIDER: S-EPMC10787503 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature