The influence of nutritional habits, body mass index and intestinal microbiota in mastocytosis on clinical symptoms using conventional culture and next generation sequencing.

ABSTRACT:

Background

Mastocytosis is a rare neoplastic disease of the bone marrow associated with the proliferation and accumulation of mast cells in various internal organs, including the gastrointestinal tract. There are few studies describing the gut microbiome of patients with mastocytosis using next generation sequencing supported using traditional culture methods. The aims of the study were, firstly, the determination of nutrition habits, composition of the intestinal microflora and BMI in mastocytosis, and secondly, analysis of mastocytosis severity and symptoms depending on the composition of the intestinal microflora.

Methods

The study included 47 patients with indolent systemic mastocytosis and 18 healthy controls. All participants gave their informed consent to participate

SUBMITTER: Harceko-Zielinska E 

PROVIDER: S-EPMC10787583 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature