Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators.

ABSTRACT: Disparities in socio-economic status (SES) predict many immune system-related diseases, and previous research documents relationships between SES and the immune cell transcriptome. Drawing on a bioinformatically-informed network approach, we situate these findings in a broader molecular framework by examining the upstream regulators of SES-associated transcriptional alterations. Data come from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a nationally representative sample of 4543 adults in the United States. Results reveal a network-of differentially expressed genes, transcription factors, and protein neighbors of transcription factors-that shows widespread SES-related dysregulation of the immune system. Mediational models suggest that body mass index (BMI) p

SUBMITTER: Ravi S 

PROVIDER: S-EPMC10787749 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature