GINv2.0: a comprehensive topological network integrating molecular interactions from multiple knowledge bases.

ABSTRACT: Knowledge bases have been instrumental in advancing biological research, facilitating pathway analysis and data visualization, which are now widely employed in the scientific community. Despite the establishment of several prominent knowledge bases focusing on signaling, metabolic networks, or both, integrating these networks into a unified topological network has proven to be challenging. The intricacy of molecular interactions and the diverse formats employed to store and display them contribute to the complexity of this task. In a prior study, we addressed this challenge by introducing a "meta-pathway" structure that integrated the advantages of the Simple Interaction Format (SIF) while accommodating reaction information. Nevertheless, the earlier Global Integrative Network (GIN) was li

SUBMITTER: Chang X 

PROVIDER: S-EPMC10787761 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature