Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions.

ABSTRACT: Macrophages are specialized phagocytes that play central roles in immunity and tissue repair. Their diverse functionalities have led to an evolution of new allogenic and autologous macrophage products. However, realizing the full therapeutic potential of these cell-based therapies requires development of imaging technologies that can track immune cell migration within tissues in real-time. Such innovations will not only inform treatment regimens and empower interpretation of therapeutic outcomes but also enable prediction and early intervention during adverse events. Here, phase-changing nanoemulsion contrast agents are reported that permit real-time, continuous, and high-fidelity ultrasound imaging of macrophages in situ. Using a de novo designed peptide emulsifier, liquid perfluorocarbon

SUBMITTER: Kim I 

PROVIDER: S-EPMC10787802 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature