Glutathione-Responsive Methotrexate Polymersomes for Potential Management of Ectopic Pregnancy.

ABSTRACT: The first-line treatment for ectopic pregnancy (EP), the chemotherapeutic methotrexate (MTX), has a failure rate of more than 10%, which can lead to severe complications or death. Inadequate accumulation of administered MTX at the ectopic implantation site significantly contributes to therapeutic failure. This study reports the first glutathione-responsive polymersomes for efficient delivery of MTX to the implantation site and its triggered release in placental cells. Fluorescence and photoacoustic imaging have confirmed that the developed polymersomes preferentially accumulate after systemic administration in the implantation site of pregnant mice at early gestational stages. The high concentrations of intracellular glutathione (GSH) reduce an incorporated disulfide bond within polymersom

SUBMITTER: Mamnoon B 

PROVIDER: S-EPMC10787806 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature