Definition and Clinical Evaluation for Trimethoprim-Sulfamethoxazole Severe Acute Respiratory Failure.

ABSTRACT:

Objectives

Trimethoprim-sulfamethoxazole (TMP-SMX)-associated severe acute respiratory distress syndrome (ARDS) has gone underrecognized. We propose the first disease definition and clinical evaluation for a novel adverse drug reaction (ADR) based on a series of recently identified rare cases of life-threatening ADRs.

Design

A retrospective study was conducted. All medical records were evaluated. Available pathology samples were sent to Massachusetts General for clinical consultation. Blood samples from surviving patients were obtained and human leukocyte antigen (HLA) analysis was performed by the Children's Mercy Hospital Genomic Center and Vanderbilt University Medical Center.

Setting

U.S. ICUs, 1996-2021.

Patients

Nineteen young patients (10-37) were identi

SUBMITTER: Miller J 

PROVIDER: S-EPMC10787807 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature