Associations between low serum levels of ANRIL and some common gene SNPs in Iranian patients with premature coronary artery disease.

ABSTRACT: Coronary artery disease (CAD) is the major cause of mortality in the world. Premature development of CAD can be attributed to women under 55 and men under 45. Many genetic factors play a part in premature CAD. Among them, ANRIL, a long noncoding RNA is located at the 9p21 risk locus, and its expression seems to be correlated with CAD. In the current study, premature CAD and control blood samples, with and without Type 2 Diabetes (T2D), were genotyped for six SNPs at the 9p21 locus. Additionally, ANRIL serum expression was assessed in both groups using real-time PCR. It was performed using different primers targeting exons 1, 5-6, and 19. The χ² test for association, along with t-tests and ANOVA, was employed for statistical analysis. In this study, we did not find any significan

SUBMITTER: Taheri Bajgan E 

PROVIDER: S-EPMC10787829 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature