Role of IFN-α in Rheumatoid Arthritis.

ABSTRACT:

Purpose of review

Type 1 interferons (IFN-I) are of increasing interest across a wide range of autoimmune rheumatic diseases. Historically, research into their role in rheumatoid arthritis (RA) has been relatively neglected, but recent work continues to highlight a potential contribution to RA pathophysiology.

Recent findings

We emphasise the importance of disease stage when examining IFN-I in RA and provide an overview on how IFN-I may have a direct role on a variety of relevant cellular functions. We explore how clinical trajectory may be influenced by increased IFN-I signalling, and also, the limitations of scores composed of interferon response genes. Relevant environmental triggers and inheritable RA genetic risk relating to IFN-I signalling are explored with emphasis o

SUBMITTER: Lin CMA 

PROVIDER: S-EPMC10787895 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature