A cost-effectiveness analysis of lung cancer screening with low-dose computed tomography and a polygenic risk score.

ABSTRACT:

Introduction

Several studies have proved that Polygenic Risk Score (PRS) is a potential candidate for realizing precision screening. The effectiveness of low-dose computed tomography (LDCT) screening for lung cancer has been proved to reduce lung cancer specific and overall mortality, but the cost-effectiveness of diverse screening strategies remained unclear.

Methods

The comparative cost-effectiveness analysis used a Markov state-transition model to assess the potential effect and costs of the screening strategies incorporating PRS or not. A hypothetical cohort of 300,000 heavy smokers entered the study at age 50-74 years and were followed up until death or age 79 years. The model was run with a cycle length of 1 year. All the transition probabilities were validated and the

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10787978 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature