Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence.

ABSTRACT:

Background

Clinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead to early manifestation of withdrawal-like signs, indicating the state of "acute dependence". As drug withdrawal is a major factor driving the progression toward regular drug intake, characterizing and understanding the features of early nicotine withdrawal may be important for the prevention and treatment of drug addiction. In this study, we corroborate the previous studies by showing that withdrawal-like signs can be precipitated after short-term nicotine exposure in mice, providing a potential animal model of acute dependence on nicotine.

Results

To model nicotine exposure from light tobacco use during the initial experimenta

SUBMITTER: Kim B 

PROVIDER: S-EPMC10788015 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature