Exploration of potential shared gene signatures between periodontitis and multiple sclerosis.

ABSTRACT:

Background

Although periodontitis has previously been reported to be linked with multiple sclerosis (MS), but the molecular mechanisms and pathological interactions between the two remain unclear. This study aims to explore potential crosstalk genes and pathways between periodontitis and MS.

Methods

Periodontitis and MS data were obtained from the Gene Expression Omnibus (GEO) database. Shared genes were identified by differential expression analysis and weighted gene co-expression network analysis (WGCNA). Then, enrichment analysis for the shared genes was carried out by multiple methods. The least absolute shrinkage and selection operator (LASSO) regression was used to obtain potential shared diagnostic genes. Furthermore, the expression profile of 28 immune cells in perio

SUBMITTER: Wu E 

PROVIDER: S-EPMC10788039 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature