Gastrodin improves osteoblast function and adhesion to titanium surface in a high glucose environment.

ABSTRACT:

Objective

To investigate the effects of gastrodin on the biological behavior of osteoblasts and osseointegration on the surface of the titanium plate in a high glucose environment, and to explore the possible regulatory mechanisms involved.

Methods

A high glucose-induced oxidative damage model of MC3T3-E1 cells was established in vitro to observe the effects of gastrodin on cellular oxidative stress, cell viability, osteogenic differentiation, mineralization, migration, and adhesion ability on the titanium surface.

Results

High glucose environment can cause oxidative stress damage to MC3T3-E1 cells, leading to a decrease in cell viability, osteogenesis, migration, adhesion and other functions. Gastrodin can upregulate the expression of antioxidant enzymes (Nrf2

SUBMITTER: Li Y 

PROVIDER: S-EPMC10788200 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature