Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup.
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ABSTRACT:
SUBMITTER: Byappanahalli AM
PROVIDER: S-EPMC10788249 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup.
Byappanahalli Anjali M AM Omoniyi Victor V Noren Hooten Nicole N Smith Jessica T JT Mode Nicolle A NA Ezike Ngozi N Zonderman Alan B AB Evans Michele K MK
iScience 20231213 1
Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select mitochondrial DNA (mtDNA) haplogroups are associated with cardiovascular disease. We hypothesized that ccf-mtDNA and plasma EV mtDNA would be associated with hypertension, sex, self-identified race, and mtDNA haplogroup ancestry. Participants were normotensive (n = 107) and hypertensive (n = 108) African American and ...[more]
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