Elevated concentrations of Neu5Ac and Neu5,9Ac₂ in human plasma: potential biomarkers of cardiovascular disease.

ABSTRACT: Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The presence of CVD is characterised by high levels of inflammation which have previously been associated with increased plasma concentrations of N-acetyl neuraminic acid (Neu5Ac). While Neu5Ac has been studied in the context of CVD, Neu5,9Ac₂ has not, despite being the second most abundant sialic acid in human plasma. A small-scale pilot study of thirty plasma samples from patients with diagnosed CVD, and thirty age and sex-matched healthy controls, was designed to gain insight into sialic acids as biomarkers for CVD and potential future areas of study. Each sample was assayed for Neu5Ac and Neu5,9Ac₂ concentrations. Mean

SUBMITTER: Cheeseman J 

PROVIDER: S-EPMC10788320 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature