Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside.

ABSTRACT: Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies, although they still face certain limitations, including high costs and toxic effects. Natural killer cells (NK cells), as a vital component of the immune system, serve as the "first responders" in the context of cancer development. In this literature review, we provide an updated understanding of NK cell development, functions, and their applications in disease therapy. Furthermore, we explore the rationale for utilizing engineered NK cell therapies, such as CAR-NK cells, and discuss the differences between CAR-T and CAR-NK cells. We also provide insights into the key elements and st

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10788349 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature