A genomic and bioinformatic-based approach to identify genetic variants for liver cancer across multiple continents.

ABSTRACT: Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk factors and liver cancer. However, the specific variants involved in this process remain under-explored. This study utilized a bioinformatics approach to identify genetic variants associated with liver cancer from various continents. Single-nucleotide polymorphisms associated with liver cancer were retrieved from the genome-wide association studies catalog. Prioritization was then performed using functional annotation with HaploReg v4.1 and the Ensembl database. The prevalence an

SUBMITTER: Ma'ruf M 

PROVIDER: S-EPMC10788354 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature