Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.

ABSTRACT:

Background

Allergen immunotherapy (AIT) is a well-established disease-modifying therapy for allergic rhinitis, yet the fundamental mechanisms underlying its clinical effect remain inadequately understood. Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy was a randomized, double-blind, placebo-controlled trial of individuals allergic to timothy grass who received 2 years of placebo (n = 30), subcutaneous immunotherapy (SCIT) (n = 27), or sublingual immunotherapy (SLIT) (n = 27) and were then followed for 1 additional year.

Objective

We used yearly biospecimens from the Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy study to identify molecular mechanisms of response.

Methods

We used longitudinal trans

SUBMITTER: Altman MC 

PROVIDER: S-EPMC10788383 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature