Porphyromonas gingivalis interaction with Candida albicans allows for aerobic escape, virulence and adherence.

ABSTRACT: In the oral cavity Candida albicans interacts with many oral bacteria, including Porphyromonas gingivalis, both physically and metabolically. The aim of this in vitro study was to characterize these interactions and study their effects on the survival of P. gingivalis. First, metabolic interactions were evaluated by counting the colony forming units (CFU) after co-culturing. The results indicated that the anaerobic bacterium P. gingivalis survives under aerobic conditions when co-cultured with C. albicans. This is due to the oxygen consumption by C. albicans as determined by a reduction in survival upon the addition of Antimycin A. By measuring the protease activity, it was found that the presence of C. albicans induced gingipain acti

SUBMITTER: de Jongh CA 

PROVIDER: S-EPMC10788424 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature