Combined transcriptomics and proteomics studies on the effect of electrical stimulation on spinal cord injury in rats.

ABSTRACT: Electrical stimulation (ES) of the spinal cord is a promising therapy for functional rehabilitation after spinal cord injury (SCI). However, the specific mechanism of action is poorly understood. We designed and applied an implanted ES device in the SCI area in rats and determined the effect of ES on the treatment of motor dysfunction after SCI using behavioral scores. Additionally, we examined the molecular characteristics of the samples using proteomic and transcriptomic sequencing. The differential molecules between groups were identified using statistical analyses. Molecular, network, and pathway-based analyses were used to identify group-specific biological features. ES (0.5 mA, 0.1 ms, 50 Hz) had a positive effect on motor dysfunction and neuronal regeneration in rats after SCI. Six

SUBMITTER: Li E 

PROVIDER: S-EPMC10788535 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature