Engineering tunable dual peptide hybrid coatings promote osseointegration of implants.

ABSTRACT: Utilizing complementary bioactive peptides is a promising surface engineering strategy for bone regeneration on osteogenesis. In this study, we designed block peptides, (Lysine)₆-capped RGD (K₆-(linker-RGD)₃) and OGP (K₆-linker-(YGFGG)₂), which were mildly grafted onto PC/Fe-MPNs through supramolecular interactions between K₆ and PC residues on the MPNs surface to form a dual peptide coating, named PC/Fe@K₆-RGD/OGP. The properties of the block peptides coating, including mechanics, hydrophilicity, chemical composition, etc., were detailly characterized by various techniques (ellipsometry, quartz crystal microbalance, X-ray photoelectron spectroscopy, water contact angle, scanning electronic microscopy and atomic f

SUBMITTER: Shou Z 

PROVIDER: S-EPMC10788622 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature